Santersus

Clinical Applications: Transplantation

Liver and lung transplantation has become the only option of therapy for patients suffering from end-stage lung and liver disease. Less than 10% of global transplantation needs are met due to shortage of good quality organs. NETs are formed in vasculature and tissues of liver and lungs during organ donation, storage and retransplantation and induce irrevocable transplant damage. Donor liver and lungs processing with NucleoCapture removes NETs and prevents organ injury, dramatically improving organ quality.

TRANSPLANTATION

NucleoCapture for Liver Transplantation

Image source: Clearance of transaminases during normothermic ex situ liver perfusion https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0215619.g002

There is massive formation of NETs in the process of liver transplantation in both donor transplant organ and recipient. Elevated NETs are associated with organ tissue ischemia, reperfusion injury and organ transplant rejection. We are investigating the use of Nucleocapture to improve transplantation outcomes.

Ex-Vivo machine perfusion is a mainstream solution to attenuate ischemia reperfusion injury to increase liver utilisation and reduce post-transplant complications.

Liver perfusion system is a self-contained unit for the preservation of transplant liver that uses normothermic machine perfusion, which seeks to recreate an environment similar to the human body.

Liver perfusion with NucleoCapture almost completely prevents liver ischemia reperfusion injury which is a main cause of graft dysfunction and mortality after liver transplantation.

NucleoCapture for Lung Transplantation

Image source: • Ex vivo lung perfusion in lung transplantation Daisuke Nakajima1 · Hiroshi Date1 Received:
12 November 2020 / Accepted: 17 February 2021 © The Japanese Association for Thoracic Surgery 2021

Ex vivo lung perfusion is a mainstream solution to attenuate ischemia reperfusion injury to increase lung utilisation rate and reduce post-transplant complications.

EVLP system is a self-contained unit for the preservation of transplant lungs that uses normothermic machine perfusion, which seeks to recreate an environment similar to the human body.

EVLP with NucleoCapture in an Acute Lung Injury model prevent ARDS and dramatically improves lung quality making 85% organs transplantable as compared with 15% on EVLP alone. Clinical studies with human lungs due QIV2022.