Clinical Applications: Transplantation
NucleoCapture for Liver Transplantation
Image source: Clearance of transaminases during normothermic ex situ liver perfusion https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0215619.g002
There is massive formation of NETs in the process of liver transplantation in both donor transplant organ and recipient. Elevated NETs are associated with organ tissue ischemia, reperfusion injury and organ transplant rejection. We are investigating the use of Nucleocapture to improve transplantation outcomes.